Mito-controversies
نویسندگان
چکیده
منابع مشابه
Mito-communications.
It has long been known that the mitochondrial genome normally mutates at a higher rate than the nuclear genome. Direct estimates of mitochondrial mutation rates can be made by sequencing individuals from mutation-accumulation lines, for which the evolutionary timescale is known exactly. Using such an approach, estimates of mutation rates have been made for a small number of species (e.g. Denver...
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The markedly high prevalence of obesity contributes to the increased incidence of chronic diseases, such as diabetes, hypertension, sleep apnea, and heart disease. Because of high prevalence of obesity in almost all countries, it has been the focus of many researches throughout the world during the recent decades. Along with increasing researches, new concepts and controversies have been emerge...
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Mitochondrial replacement therapy (MRT) is a human reproductive technology by which the mitochondria of a recipient’s eggs are effectively replaced by those of a donor, potentially eliminating harmful mitochondrial mutations carried by the recipient. However, concerns have been raised that MRT may lead to problems due to incompatibilities between the nuclear genome of the recipient and mitochon...
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The appearance of an animal species is a complex phenotype partially encoded in its genome. Previous work on linking genotype to visually-identifiable phenotypes has focused on univariate or low-dimensional traits such as eye color1, principal variations in skeletal structure2 and height3, as well as on the discovery of specific genes that contribute to these traits. Here, we go beyond single t...
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Intraoperative awareness, with or without recall, continues to be a topic of clinical significance and neurobiological interest. In this article, we review evidence pertaining to the incidence, sequelae, and prevention of intraoperative awareness. We also assess which aspects of the complication are well understood (i.e. non-controversial) and which require further research for clarification (i...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2008
ISSN: 0003-3022
DOI: 10.1097/01.anes.0000299750.34472.93